Akademik Veri Yönetim Sistemi
Sustainable Chemistry and Pharmacy, cilt.46, 2025 (SCI-Expanded)
A simple, rapid, hand-shaking-assisted, and practical Box-Behnken-designed microextraction approach using a newly synthesized Organic Acid-assisted Magnetic Deep Eutectic Solvent (OA-MDES) was established for the first time for the UV–vis spectrophotometric determination of Carmoisine (E122) in foodstuffs and cosmetics. Five different types of OA-MDES were prepared to achieve the quantitative microextraction of Carmoisine. The important independent microextraction variables, including pH, amount of NaCl, and the type and volume of the dispersive solvent and OA-MDES, were investigated and optimized using chemometric Box-Behnken experimental design. The quadratic microextraction model with R2 = 0.9997 was designed as the best-fitting chemometric approach. Limit of detection, preconcentration factor, and linear dynamic range were determined as 0.03 μg/mL, 100, and 0.1–150 μg/mL, respectively. The determination of Carmoisine in real samples was conducted using analyte addition-recovery tests. Carmoisine contents of foodstuffs, soft drinks, and cosmetic samples were determined to be between 7.3 and 22.1 μg/mL and 16.7–166.0 μg/g, with microextraction recovery values ranging from 89 % to 98 %. Analytical GREEnness and Blue Applicability Grade Index metric tools were used to evaluate the sustainability of the method. Analytical greenness score of 0.70/1.00 and applicability point of 67.5/100 were determined for the developed OA-MDES microextraction method.