Assessment of the Association Between Complete Blood Cell Parameters, Levels of Vitamin B12 and Folate, Decreased Iron Storage and Recurrent Vasovagal Syncope Episodes

Ayanoglu M., KÖMÜRLÜOĞLU TAN A., ÇELİK E., Celik S. F., Tosun A.

MEANDROS MEDICAL AND DENTAL JOURNAL, cilt.23, sa.3, ss.373-378, 2022 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4274/meros.galenos.2022.83435
  • Dergi Adı: MEANDROS MEDICAL AND DENTAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.373-378
  • Anahtar Kelimeler: Vasovagal syncope, fainting, serum ferritin, complete blood count, mean platelet volume, mean corpuscular hemoglobin concentration, DEFICIENCY, CHILDREN, DIAGNOSIS
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: To evaluate the relationship between recurrent vasovagal syncope (VVS) and complete blood cell parameters, serum levels of ferritin, vitamin B12, and folate.Materials and Methods: This retrospective study included patients with recurrent VVS and healthy controls. Children and adolescents presenting with at least two VVS episodes were included. Exclusion criteria were as follows; having an electrocardiogram abnormality, patients without an evident trigger before fainting, having an infection, having a history of chronic disease, and taking any medications or vitamin supplements, including folate, vitamin B12, and iron.Results: A total of 44 patients and 66 healthy controls were included. There were no significant differences between the groups in terms of age and gender. Mean corpuscular hemoglobin concentration (MCHC) (p=0.014), mean platelet volume (MPV) (p=0.020), and levels of ferritin (p<0.0001) were significantly lower in the patient group. No significant differences were found between the groups with respect to other laboratory parameters. Binary logistic regression analysis showed that every 1-unit decrease in serum ferritin constitutes a 0.972 [950k) confidence interval (CI)= 0.954-0.990] fold risk. Also, every 1-unit decrease in MPV constitutes a 0.453 (950k) CI=0.275-0.745) fold risk of VVS.Conclusion: This study showed lower levels of serum ferritin, smaller platelet sizes, and lower levels of MCHC. Additionally, smaller platelet sizes and lower levels of ferritin were independent risk factors.