Amelioration of Cerebral Vasospasm and Secondary Injury by Vigabatrin After Experimental Subarachnoid Hemorrhage in the Rabbit

Fesli, Ramazan; Bektasoglu, Pinar; Gurer, Bora; Arikok, Ata; Ozturk, Ozden; BOZKURT, HÜSEYİN; Kertmen, Hayri

doi:10.1016/j.wneu.2020.05.230

Amelioration of Cerebral Vasospasm and Secondary Injury by Vigabatrin After Experimental Subarachnoid Hemorrhage in the Rabbit

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Fesli R., Bektasoglu P. K. , Gurer B., Arikok A. T. , Ozturk O. C. , BOZKURT H. , ...More

WORLD NEUROSURGERY, vol.141, 2020 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 141
Publication Date: 2020
Doi Number: 10.1016/j.wneu.2020.05.230
Title of Journal : WORLD NEUROSURGERY

Abstract

BACKGROUND: Vigabatrin, an antiepileptic drug, increases the level of gamma aminobutyric acid in the brain by inhibiting its catabolism. Because gamma aminobutyric acid has been proved to have vasodilatory effects, in the present study, we investigated the effect of vigabatrin to treat experimental subarachnoid hemorrhage (SAH)-induced vasospasm.