Amelioration of Cerebral Vasospasm and Secondary Injury by Vigabatrin After Experimental Subarachnoid Hemorrhage in the Rabbit

Fesli R., Bektasoglu P. K., Gurer B., Arikok A. T., Ozturk O. C., BOZKURT H., ...More

WORLD NEUROSURGERY, vol.141, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 141
  • Publication Date: 2020
  • Doi Number: 10.1016/j.wneu.2020.05.230
  • Journal Name: WORLD NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Index Islamicus, MEDLINE, Veterinary Science Database
  • Sivas Cumhuriyet University Affiliated: No

Abstract

BACKGROUND: Vigabatrin, an antiepileptic drug, increases the level of gamma aminobutyric acid in the brain by inhibiting its catabolism. Because gamma aminobutyric acid has been proved to have vasodilatory effects, in the present study, we investigated the effect of vigabatrin to treat experimental subarachnoid hemorrhage (SAH)-induced vasospasm.