Akademik Veri Yönetim Sistemi
Polyhedron, cilt.289, 2026 (SCI-Expanded, Scopus)
Cu-MOF, Ni-MOF, and Co-MOF were synthesized and characterized using X-ray diffraction (XRD), Raman spectroscopy, UV–Vis spectroscopy, and scanning electron microscopy (SEM). These analyses confirmed the successful formation of crystalline frameworks with distinct optical and morphological features modulated by the central metal ion. Photocatalytic studies using Congo Red as a model pollutant revealed that Cu-MOF exhibited the highest visible-light degradation efficiency (∼96% within 120 min), followed by Co-MOF (∼89%) and Ni-MOF (∼80%). These differences were attributed to variations in light absorption, charge separation efficiency, and crystal morphology. Furthermore, in this study, the biological activities of three metal-organic framework (MOF) compounds-Cu-MOF, Ni-MOF, and Co-MOF-were systematically investigated in terms of their amylolytic, DNA cutting, antimicrobial, biofilm inhibition, and microbial cell viability inhibition properties. Cu-MOF demonstrated strong α-amylase inhibitory activity across all tested concentrations, suggesting its potential as an effective antidiabetic agent. In contrast, Co-MOF enhanced α-amylase activity at low concentrations, indicating potential applicability in starch-based biotechnological processes. Ni-MOF showed a concentration-dependent inhibitory profile on enzyme activity. All three MOFs were found to induce double-strand DNA breaks at varying concentrations, indicating significant genotoxic potential. In antimicrobial assays, Cu-MOF exhibited the lowest minimum inhibitory concentration (MIC) values against Enterococcus faecalis and Legionella pneumophila (8 mg/L), indicating superior activity compared to Ni-MOF and Co-MOF. However, all MOFs displayed broad-spectrum antimicrobial effects, particularly against Gram-positive bacteria. In biofilm inhibition studies, Cu-MOF showed the highest inhibition rates against both Staphylococcus aureus (95.33%) and Pseudomonas aeruginosa (85.67%) at 50 mg/L, outperforming Co-MOF and Ni-MOF. Additionally, Cu-MOF demonstrated the most pronounced inhibitory effect on E. coli viability at low concentrations, whereas Ni-MOF and Co-MOF achieved complete inhibition at 50 mg/L. Overall, the findings highlight the multifunctional bioactivities of MOF compounds, particularly Cu-MOF, and their potential applications in antimicrobial therapy, enzyme inhibition, and biotechnological processes. However, their toxicologic effects warrant further investigation to ensure safety in potential biomedical applications. Collectively, these results underscore the dual functionality of MOF compounds-especially Cu-MOF-as efficient photocatalysts and biologically active agents with promising biomedical and biotechnological applications.