I-131 is one of the radioisotopes in nuclear medicine procedures for diagnostic and treatment purposes. It decays to Xe-131 by emitting beta particles. In this study, we have investigated the reproduction possibility of I-131 from Xe-131 by using different reactions, including a photonuclear reaction step. We have used TALYS computer program for calculating cross-sections of the reactions. It was seen that it was not an easy task to reproduce I-131 from its decay product Xe-131 because of low reaction cross-section values. According to the results, we have seen that the calculations are in harmony with the TENDL 2014 database.