SYNTHESIZE AND STABILITY ANALYSIS OF PEGYLATED NANOGRAPHENE OXIDE FOR DELIVERY OF DOXORUBICIN

Cakmak N., Tezel G. B.

REVISTA ROMANA DE MATERIALE-ROMANIAN JOURNAL OF MATERIALS, cilt.49, sa.3, ss.346-351, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 3
  • Basım Tarihi: 2019
  • Dergi Adı: REVISTA ROMANA DE MATERIALE-ROMANIAN JOURNAL OF MATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.346-351
  • Anahtar Kelimeler: nanographene oxide (NGO), nanostructured drug carrier, stability, DOX, PEGylated, GRAPHENE-BASED NANOMATERIALS, DRUG-DELIVERY, POLYETHYLENE-GLYCOL, CANCER, THERAPY, FUNCTIONALIZATION, ADRIAMYCIN, CONJUGATE
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

In this study, graphene oxide nanoparticle (NGO) was fabricated via modified Hummers' method and then modified with amine terminated 4-armed PEG to enhance the biocompatibility and stability of nano drug carrier. In our strategy, Doxorubicin (DOX) was used as a model drug. DOX loading onto NGO-PEG was synthesized by simply mixing with the NGO-PEG solution at pH 7 overnight. NGO, NGO-PEG and NGO-PEG-DOX was characterized by power X-ray diffraction, scanning electron microscopy, and UV spectroscopy. Stability analysis was performed with zeta potential. The experimental results showed that the zeta potential analysis values were above +/- 40 mV. NGO-PEG-DOX is still had very good dispersion stability even after 45 days. Therefore, this drug loaded product can be good candidate for treatment of cancer.