SYNTHESIZE AND STABILITY ANALYSIS OF PEGYLATED NANOGRAPHENE OXIDE FOR DELIVERY OF DOXORUBICIN


Cakmak N. , Tezel G. B.

REVISTA ROMANA DE MATERIALE-ROMANIAN JOURNAL OF MATERIALS, vol.49, no.3, pp.346-351, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2019
  • Title of Journal : REVISTA ROMANA DE MATERIALE-ROMANIAN JOURNAL OF MATERIALS
  • Page Numbers: pp.346-351

Abstract

In this study, graphene oxide nanoparticle (NGO) was fabricated via modified Hummers' method and then modified with amine terminated 4-armed PEG to enhance the biocompatibility and stability of nano drug carrier. In our strategy, Doxorubicin (DOX) was used as a model drug. DOX loading onto NGO-PEG was synthesized by simply mixing with the NGO-PEG solution at pH 7 overnight. NGO, NGO-PEG and NGO-PEG-DOX was characterized by power X-ray diffraction, scanning electron microscopy, and UV spectroscopy. Stability analysis was performed with zeta potential. The experimental results showed that the zeta potential analysis values were above +/- 40 mV. NGO-PEG-DOX is still had very good dispersion stability even after 45 days. Therefore, this drug loaded product can be good candidate for treatment of cancer.