The Enterobacter cloacae complex, a member of the genus Enterobacter, consists of a group of bacteria that are responsible for serious infections in human beings. A recently identified member of the group, Enterobacter ludwigii sp, is an emerging source of clinically important infections, but, up until now, there has been no report of catheter related bacteremia due to Enterobacter ludwigii sp. in hemodialysis patients. We report a hemodialysis patient with catheter related bacteremia due to Enterobacter ludwigii sp. whose infection improved only partially by antibiotics that were expected to be fully effective, based on antibiotic susceptibility testing; the infection could be cured only after removal of the catheter.