Therapeutic Potential of Isoflavones with an Emphasis on Daidzein

Alshehri M. M., Sharifi-Rad J., Herrera-Bravo J., Jara E. L., Salazar L. A., Kregiel D., ...Daha Fazla

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, cilt.2021, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 2021
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1155/2021/6331630
  • Dergi Adı: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Compendex, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.