Knowledge of variation in facial soft tissue thickness is important for forensic anthropologists, dentists, and plastic surgeons. Forensic anthropologists use such information as a guide in facial reconstruction and superimposition methods. The purpose of this study was to measure facial tissue thicknesses of adult males and females of Turkish origin across different types of occlusion, and to compare the results with each other and with values obtained for other populations. The study was conducted on 200 healthy individuals. The analysis of facial tissue thickness included 20 landmarks (10 dentoskeletal and 10 soft tissue) and 10 linear variables. Sex-based variation in facial tissue thickness was noted. The highest soft tissue thickness values were observed in the group with Class III occlusion type at Sn-A point for both the females (16.9, SD = 2.4) and the males (17.8, SD = 3.3). In the Class I group, the highest tissue depth was observed at Sn-A point (15.3, SD = 2.1) in females, and at Li-Id point (17.1, SD = 1.9) in males. In the Class II group, contrary to the findings for Class I, the highest soft tissue depth was at Li-Id point (16.0, SD = 1.4) in females, and at Sn-A point (18.1, SD = 2.6) in males. In conclusion, facial tissue thickness varied in adults depending on the sex and on the type of occlusion. (C) 2011 Elsevier GmbH. All rights reserved.