Evaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models
Vitae, cilt.31, sa.2, 2024 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 2
- Basım Tarihi: 2024
- Doi Numarası: 10.17533/udea.vitae.v31n2a352429
- Dergi Adı: Vitae
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, Directory of Open Access Journals
- Anahtar Kelimeler: Allium cepa, Allium sativum, Cicer arietinum, Rabeprazole sodium, Toxicity monitoring tools
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings. Objective: To evaluate the toxic effects of RPZ sodium (RPZ-Na) using plant-based eukaryotic test systems. Methods: The toxic effect of RPZ-Na (0.025-0.4 mM) was evaluated on Allium cepa, Allium sativum, and Cicer arietinum at different exposure times using CuSO4 as a reference standard. Results: RPZ-Na concentration-dependently reduced the root length of A. cepa and A. sativum, as well as the shoot and root lengths of C. arietinum. RPZ-Na at 0.1 to 0.4 µg/mL and at 48 h exposure time exerted toxic effects on the tested systems. Conclusions: RPZ-Na exerted a concentration-and time-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use.