Bölgemizdeki Streptococcus pneumoniae suşlarının bazı antibiyotiklere direnç durumu


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Elaldı N.

KLIMIK JOURNAL, cilt.12, ss.13-15, 1999 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 12 Konu: 1
  • Basım Tarihi: 1999
  • Dergi Adı: KLIMIK JOURNAL
  • Sayfa Sayıları: ss.13-15

Özet

KOAH’l› hastalarda akut atak etkeni olarak üretilen 35 Streptococcus pneumoniae suflu çal›flmaya al›nd›. Bu sufllar›n penisilin, tetrasiklin, kloramfenikol, eritromisin, seftriakson ve sefotaksime direnç durumu disk difüzyon ve agar dilüsyon yöntemleri ile belirlendi. Disk difüzyon ve agar dilüsyon testi NCCLS kriterlerine uyularak %5 koyun kanl› Mueller-Hinton agar› kullan›larak yap›ld›. S.pneumoniae’nin disk difüzyon yöntemi ile oksasilin direnci %23 bulunurken, agar dilüsyon yöntemi ile penisiline %14 oran›nda düflük düzeyde direnç saptand›; penisiline yüksek düzeyde direnç tespit edilmedi. Disk difüzyon yöntemi ile S.pneumoniae sufllar› tetrasikline %28, kloramfenikole %14, eritromisine %17 oran›nda dirençli bulunurken, sefotaksim ve seftriaksona direnç saptanmad›. Agar dilüsyon yöntemi ile tetrasiklin, kloramfenikol, eritromisin, sefotaksim ve seftriaksona direnç bulunmazken, %9’u tetrasikline ve %14’ü kloramfenikole orta duyarl› bulundu. S.pneumoniae sufllar› %9 oran›nda multipl dirence (≥ 2 antibiyoti¤e direnç) sahipti.

The resistance rate of Streptococcus pneumoniae strains to some antibiotics in our region. 35 Streptococcus pneumoniae strains isolated from patients who had acute exacerbation of chronic obstructive lung disease were included in this study. The resistance to penicillin, tetracycline, chloramphenicol, erythromycin, ceftriaxone, and cefotaxime were determined by using disk diffusion and agar dilution methods. These methods were performed on Mueller-Hinton agar with 5% sheep blood according to NCCLS criteria. The resistance rate of S.pneumoniae to oxacillin was 23% by using disk diffusion method, whereas no high-level resistance to penicillin was determined by agar dilution method. The lowlevel resistance rate was 14%. The resistance rate of S.pneumoniae strains determined by disk diffusion method to tetracycline, chloramphenicol, and erythromycin was 28, 14, and 17%, respectively. However, there was no resistance to ceftriaxone and cefotaxime. Although it was not observed any resistance to tetracycline, chloramphenicol, erythromycin, ceftriaxone and cefotaxime by agar dilution method, we found 9% and 14% of isolates as moderately susceptible to tetracycline and chloramphenicol, respectively. Of 35 strains, three (9%) had multiple resistance (i.e, resistant to ≥ 2 agents).