Akademik Veri Yönetim Sistemi
Current Topics in Medicinal Chemistry, cilt.22, sa.3, ss.229-246, 2022 (SCI-Expanded)
© 2022 Bentham Science Publishers.Medicinal plants have a long history of use as food and remedy in traditional and mod-ern societies. They have been used as herbal drugs and sources of novel bioactive compounds. They provide a wide array of chemical compounds, many of which can not be synthesized via current synthesis methods. Natural products may provide aromatase inhibitory activity through various pathways and may act clinically effective for treating pathologies associated with excessive aro-matase secretion, including breast, ovarian, and endometrial cancers, endometriosis, uterine fi-broid, benign prostatic hyperplasia (BPH), prostate cancer, infertility, and gynecomastia. Recent studies have shown that natural products with aromatase inhibitory activity can also be good op-tions against secondary recurrence of breast cancer by exhibiting chemopreventive effects. There-fore, screening for new plant-based aromatase inhibitors may provide novel leads for drug discovery and development, particularly with increased clinical efficacy and decreased side effects.