The aim of the present study was to estimate the co-morbidity of migraine and major depression in the Turkish population. The households were selected randomly from all district areas. The study included 947 subjects aged greater than or equal to 18 years. The diagnosis of migraine was made according to the criteria of the International Headache Society. The diagnosis of major depression was made according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Migraine was identified in 163 subjects. Major depression was identified in 155 subjects, and in 53 subjects with migraine. The lifetime prevalence of major depression was approximately three times higher in persons with migraine in this Turkish population.