Effect of hypothyroidism on the purinergic responses of corpus cavernosal smooth muscle in rabbits

Yildirim M. K., Bagcivan İ., Sarac B., Kilicarslan H., Yildirim Ş., Kaya T.

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.40, no.3, pp.691-699, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1007/s11255-008-9332-0
  • Journal Name: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.691-699
  • Keywords: impotence, hypothyroidism, corpus cavernosum, ENDOTHELIUM-DEPENDENT RELAXATION, NITRIC-OXIDE, POTENT RELAXANT, ADENOSINE, RECEPTORS, P2Y, PURINOCEPTORS, PHYSIOLOGY, ERECTION
  • Sivas Cumhuriyet University Affiliated: Yes

Abstract

Aims Several studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. Hypothyroidism has been reported to occur in 6% of impotent men. In the present study, we examined purinergic relaxation responses in hypothyroidism in an experimental rabbit model and compared them with controls to evaluate the possible involvement of the purinergic pathway.