Sequential determination of serum viral titers, virus-specific IgG antibodies, and TNF-alpha, IL-6, IL-10, and IFN-gamma levels in patients with Crimean-Congo hemorrhagic fever

Kaya, Safak; ELALDI, NAZİF; Kubar, Ayhan; GÜRSOY, NEVCİHAN; YILMAZ, MERAL; KARAKUŞ, GÜLDEREN; GÜNEŞ, TURABİ; Polat, ZÜBEYDA; GÖZEL, MUSTAFA; ENGİN, AYNUR; DÖKMETAŞ, İLYAS; BAKIR, MEHMET; Yilmaz, Neziha; ŞENCAN, MEHMET

doi:10.1186/1471-2334-14-416

Sequential determination of serum viral titers, virus-specific IgG antibodies, and TNF-alpha, IL-6, IL-10, and IFN-gamma levels in patients with Crimean-Congo hemorrhagic fever

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Kaya S., ELALDI N. , Kubar A., GÜRSOY N. , YILMAZ M. , KARAKUŞ G. , ...More

BMC INFECTIOUS DISEASES, vol.14, 2014 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 14
Publication Date: 2014
Doi Number: 10.1186/1471-2334-14-416
Title of Journal : BMC INFECTIOUS DISEASES

Abstract

Background: Although there have been a number of studies on the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) recently, knowledge on this topic is still insufficient. This study aims to reveal the kinetics of serum CCHF virus (CCHFV) titers, serum levels of anti-CCHFV immunoglobulin (Ig) G, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, and interferon (IFN)-gamma in CCHF patients.