Synthesis and structural characterization BODIPY-based compounds for fluorescence sensing of β-amyloid aggregates

Kırpık H., Elmes R. B., SAYIN K., Kose M.

Journal of Molecular Structure, cilt.1324, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1324
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.molstruc.2024.140848
  • Dergi Adı: Journal of Molecular Structure
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Anahtar Kelimeler: Alzheimer's disease, BODIPY, Fluorescence sensor, Squaric acid ester, Β-Amyloid
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Alzheimer's disease (AD) is a neurodegenerative disorder associated with aging. According to the amyloid cascade hypothesis, the aggregation and accumulation of β-amyloid (Aβ) peptides in the brain as Aβ plaques is a critical process in the pathogenesis of AD. Among the existing diagnosis methods, fluorescence detection of β-amyloid (Aβ) has emerged as an alternative method due to its advantages such as real-time detection, low cost, not exposed to radiation, and high resolution for early diagnosis of Alzheimer's disease (AD). In this study, we designed and synthesized BODIPY-based compounds (BODIPY-3, BODIPY-4 and BODIPY-5) for the fluorescence detection of Aβ aggregates. In the fluorescence studies for detecting Aβ, BODIPY-5 with the squaric acid ester unit at the meso position of the BODIPY core showed a promising effect with an 11.7 μM Kd value.