Comparison of the Effects of Contractubex Gel and Benzothiazole After Topical Application in an Experimental Model of Epidural Fibrosis in Rats

BOZKURT, HÜSEYİN; Bozkurt, Emel; ÖZPINAR, HÜLYA; Arac, Densel; KAYA, İSMAİL; Ozer, Hidir; Egilmez, Reyhan

doi:10.1016/j.wneu.2018.06.044

Comparison of the Effects of Contractubex Gel and Benzothiazole After Topical Application in an Experimental Model of Epidural Fibrosis in Rats

Atıf İçin Kopyala

BOZKURT H. , Bozkurt E. C. , ÖZPINAR H. , Arac D., KAYA İ. , Ozer H., ...Daha Fazla

WORLD NEUROSURGERY, cilt.117, 2018 (SCI İndekslerine Giren Dergi)

Cilt numarası: 117
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.wneu.2018.06.044
Dergi Adı: WORLD NEUROSURGERY

Özet

BACKGROUND: Postoperative epidural adhesion is a frequent cause of failed back surgery syndrome, manifesting with back and leg pain or neurologic deficits. Development of preventive measures for epidural adhesion after laminectomy is critical to improve outcomes of lumbar surgery. We hypothesized that positive effects of topical application of Contractubex (CTX) gel and benzothiazole (BT) individually and in combination could aid in preventing epidural fibrosis in a rat laminectomy model.