Comparison of the Effects of Contractubex Gel and Benzothiazole After Topical Application in an Experimental Model of Epidural Fibrosis in Rats

BOZKURT H., Bozkurt E. C., ÖZPINAR H., Arac D., KAYA İ., Ozer H., ...Daha Fazla

WORLD NEUROSURGERY, cilt.117, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 117
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.wneu.2018.06.044
  • Dergi Adı: WORLD NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Epidural fibrosis, Laminectomy, Rat, Topical BT, Topical Contractubex gel, HYPERTROPHIC SCARS, LAMINECTOMY MODEL, BACK SURGERY, PREVENTION, HEPARIN, ALLANTOIN, EXTRACT, MIXTURE, ACID, PAIN
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

BACKGROUND: Postoperative epidural adhesion is a frequent cause of failed back surgery syndrome, manifesting with back and leg pain or neurologic deficits. Development of preventive measures for epidural adhesion after laminectomy is critical to improve outcomes of lumbar surgery. We hypothesized that positive effects of topical application of Contractubex (CTX) gel and benzothiazole (BT) individually and in combination could aid in preventing epidural fibrosis in a rat laminectomy model.