Comparison of the Effects of Contractubex Gel and Benzothiazole After Topical Application in an Experimental Model of Epidural Fibrosis in Rats

BOZKURT H. , Bozkurt E. C. , ÖZPINAR H. , Arac D., KAYA İ. , Ozer H., ...More

WORLD NEUROSURGERY, vol.117, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 117
  • Publication Date: 2018
  • Doi Number: 10.1016/j.wneu.2018.06.044
  • Title of Journal : WORLD NEUROSURGERY

Abstract

BACKGROUND: Postoperative epidural adhesion is a frequent cause of failed back surgery syndrome, manifesting with back and leg pain or neurologic deficits. Development of preventive measures for epidural adhesion after laminectomy is critical to improve outcomes of lumbar surgery. We hypothesized that positive effects of topical application of Contractubex (CTX) gel and benzothiazole (BT) individually and in combination could aid in preventing epidural fibrosis in a rat laminectomy model.