Effects of meloxicam and flunixin meglumine on oxidative stress and pregnancy factors in Awassi sheep

Akkuş T., Yaprakcı Ö., Günal İ., EKİCİ M., Emre B., Korkmaz Ö., ...Daha Fazla

Veterinary Record, cilt.196, sa.12, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 196 Sayı: 12
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1002/vetr.4908
  • Dergi Adı: Veterinary Record
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Veterinary Science Database, DIALNET
  • Anahtar Kelimeler: early pregnancy factors, fertility, NSAID, oxidative stress, sheep
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background: This study aimed to evaluate the effects of administering flunixin meglumine (FM) and meloxicam (M) on specific days post-mating on progesterone (P4), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), pregnancy-specific protein B (PSPB), pregnancy-associated glycoprotein (PAG) concentrations and fertility parameters in Awassi sheep. Methods: Seventy-five Awassi sheep were divided into three groups of 25: control, M and FM. On days 9 and 10 post-mating, the control group received saline, the M group received 0.5 mg/kg M and the FM group received 2.2 mg/kg FM. Blood samples were collected on days 8, 9, 10, 11, 12 and 17 post-mating. Results: Statistically significant time-dependent differences in P4, TAS, TOS, OSI, PSPB and PAG concentrations were found between the groups (p < 0.001). TAS was highest in the M group and lowest in the control group (p < 0.001). TOS was higher in the control group and lower in the M group (p < 0.001). PSPB and PAG were highest in the control group and lowest in the M group (p < 0.05). Limitation: Further studies with larger sample sizes are needed to confirm the findings. Conclusion: FM and M significantly affected oxidative stress parameters and early pregnancy factors but not fertility parameters.