Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

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Sharifi-Rad J., Rapposelli S., Sestito S., Herrera-Bravo J., Arancibia-Diaz A., Salazar L. A., ...Daha Fazla

JOURNAL OF PERSONALIZED MEDICINE, cilt.12, sa.9, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 12 Sayı: 9
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3390/jpm12091515
  • Dergi Adı: JOURNAL OF PERSONALIZED MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Directory of Open Access Journals
  • Anahtar Kelimeler: Alzheimer's disease, phytochemicals, neuroinflammation, oxidative damage, protein aggregation, molecular mechanisms, neuroprotective effects, AMYLOID-BETA PEPTIDE, CELL-DEATH, COGNITIVE IMPAIRMENT, CHLOROGENIC ACID, NEURODEGENERATIVE DISEASES, ANTIOXIDATIVE ACTIVITIES, FRUIT POLYPHENOLS, SH-SY5Y CELLS, DOUBLE-BLIND, INFLAMMATION
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Alzheimer's disease (AD) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence of A beta-amyloid peptide, Tau protein, oxidative stress, and an exacerbated neuro-inflammatory response. This review aims to offer an updated compendium of the most recent and promising advances in AD treatment through the administration of phytochemicals. The literature survey was carried out by electronic search in the following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, and Web of Science regarding published works that included molecular mechanisms and signaling pathways targeted by phytochemicals in various experimental models of Alzheimer's disease in vitro and in vivo. The results of the studies showed that the use of phytochemicals against AD has gained relevance due to their antioxidant, anti-neuroinflammatory, anti-amyloid, and anti-hyperphosphorylation properties of Tau protein. Some bioactive compounds from plants have been shown to have the ability to prevent and stop the progression of Alzheimer's.