Investigation of Antiepileptic and Anticancer Properties of Some Plant Species Traditionally Used in Turkey

ÖZPINAR H., BOSTANCI H. E., Hurmet M., KOÇYİĞİT Ü. M.

Latin American Journal of Pharmacy, cilt.43, sa.3, ss.618-625, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 3
  • Basım Tarihi: 2024
  • Dergi Adı: Latin American Journal of Pharmacy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.618-625
  • Anahtar Kelimeler: Alyssum alyssoides, Centaurea solstitialis, Erodium cicutarium, Leontice leontopetalum, Tragopogon reticulatus
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

The study investigated the antiepileptic and anticancer properties of water and ethanol extracts from plant species traditionally used in Turkey, including Centaurea solstitialis subsp. solstitialis (CSS), Tragopogon reticulatus (TR), Erodium cicutarium subsp. cicutarium (ECC), Alyssum alyssoides (AA) and Leontice leontopetalum subsp. leontopetalum (LLL) using apoptosis and cell cycle studies. In the investigation of the antiepileptic properties of plant extracts, the effects on the activities of carbonic anhydrase I and II isoenzymes were measured spectrophotometrically. In anticancer studies, all extracts were applied to human stomach cancer cell line (AGS), human breast cancer cell line (MCF7) and rat glioma cell line (C6) and their cytotoxicity in healthy mouse fibroblast cell line (L929) was compared using the MTT method. All extracts of ECC inhibited carbonic anhydrase I and II isoenzymes at lower concentrations than the standard substance. However, aqueous extracts of all plants had a highly toxic effect on rat glioma cell line (C6), without damaging healthy cells.