Akademik Veri Yönetim Sistemi
Journal of Molecular Structure, cilt.1337, 2025 (SCI-Expanded)
In this study, three heterocyclic Schiff base ligands (LH) were synthesized through the reaction of 2-aminomethyl thiophene, 2-aminomethyl pyridine, and 2-aminomethyl piperidine amines with 2-hydroxybenzaldehyde. Subsequently, their corresponding metal complexes with platinum(II) and palladium(II) salts were prepared. The ligands act monoanionic, coordinating to the metal center through the O atom of the phenol and N atom of the imine, forming a neutral bis-chelating square-planar complex [ML2]. The ligands and their related Pd(II) and Pt(II) complexes were characterized using FT-IR, 1H NMR, 13C NMR, and mass spectrometry. Additionally, the structure of the C1 complex was elucidated through single-crystal X-ray analysis. When the biological activities of the synthesized compounds were examined, it was found that compound C1 was more efficient than cisplatin in killing breast cancer cells with an IC50 dose (31.80 ± 4.05 µM) as a result of MTT studies. The results obtained in flow cytometry studies coincide with these data. In the antioxidant studies obtained using the FRAP method, it was determined that the synthesized compounds did not have any antioxidant power.