Evaluation of Serum Perforin, Caspase-3, sFasL and M-30 Levels as Apoptotic Markers in Children With Crimean-Congo Hemorrhagic Fever


Guven A. S. , SANCAKDAR E. , UYSAL E. B. , KAYA A. , OFLAZ M. B. , KARAPINAR H. , ...More

PEDIATRIC INFECTIOUS DISEASE JOURNAL, vol.34, no.2, pp.208-213, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1097/inf.0000000000000530
  • Title of Journal : PEDIATRIC INFECTIOUS DISEASE JOURNAL
  • Page Numbers: pp.208-213

Abstract

Background: Apoptosis is a main regulator in responses of cellular immunity throughout systemic viral infections. Perforin, soluble Fas ligand, caspase-3 and caspase-cleaved cytokeratin-18 (M-30) are mediators of apoptosis. The aim of this study is the evaluation of Crimean-Congo hemorrhagic fever (CCHF) disease changes in the levels of these apoptotic markers and the relation of these changes with disease severity.