Evaluation of Serum Perforin, Caspase-3, sFasL and M-30 Levels as Apoptotic Markers in Children With Crimean-Congo Hemorrhagic Fever

Guven A. S., SANCAKDAR E., UYSAL E. B., KAYA A., OFLAZ M. B., KARAPINAR H., ...Daha Fazla

PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.34, sa.2, ss.208-213, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1097/inf.0000000000000530
  • Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.208-213
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background: Apoptosis is a main regulator in responses of cellular immunity throughout systemic viral infections. Perforin, soluble Fas ligand, caspase-3 and caspase-cleaved cytokeratin-18 (M-30) are mediators of apoptosis. The aim of this study is the evaluation of Crimean-Congo hemorrhagic fever (CCHF) disease changes in the levels of these apoptotic markers and the relation of these changes with disease severity.