Determination of paracetamol in synthetic urea and pharmaceutical samples by shaker-assisted deep eutectic solvent microextraction and spectrophotometry

Dogan B., ELİK A., ALTUNAY N.

MICROCHEMICAL JOURNAL, cilt.154, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 154
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.microc.2020.104645
  • Dergi Adı: MICROCHEMICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Food Science & Technology Abstracts, Index Islamicus, Veterinary Science Database
  • Anahtar Kelimeler: Paracetamol, Deep eutectic solvent, Spectrophotometry, Microextraction, Pharmaceutical, PHENOLIC-COMPOUNDS, EXTRACTION, WATER, MEDIA, PESTICIDES, SPECIATION, BLOOD, IRON, OIL
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

In the present study, a new, simple and cheap shaker-assisted deep eutectic solvent microextraction (SA-DESME) procedure was developed for extraction of paracetamol in synthetic urea and pharmaceutical samples prior to its determination by UV-VIS spectrophotometer. The SA-DES-ME procedure is based on the selective extraction of paracetamol which deep eutectic solvents (DESs) prepared with choline chloride (ChCI)/betaine (Bet) and different hydrogen bond donors (HBDs).The DESs was used as the extraction solvent for the separation of the paracetamol-containing complex from the sample solution. Optimum values of experimental parameters were determined by univariate optimization method. Under optimum conditions, analytical results such as good linearity (50-800 mu g L-1), quantitative recoveries (94.2-107.1%), low detection limit (14.9 mu g L-1), and high sensitivity enhancement factor (135) were obtained using the proposed method. Additionally, the relative standard deviations (RSDs%) were less than 3.3% for repeatability and reproducibility analysis. The proposed procedure was successfully applied to the extraction and determination of paracetamol in pharmaceutical samples and synthetic urea using standard addition.