Evaluation of Serum Glucagon-like Peptide 1 and Vitamin D Levels in Elderly Patients with Bone Fracture.

Pazarcı Ö., Dogan H. O., Kilinc S., Çamurcu Y.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre, cilt.29, ss.219-224, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1159/000502132
  • Dergi Adı: Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.219-224
  • Anahtar Kelimeler: Vitamin D, Bone, Fracture, Elderly patients, Glucagon-like peptide-1, RECEPTOR AGONISTS, INCRETIN HORMONES, PREVENTION, DEFICIENCY, METABOLISM, QUALITY, GLP-1
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objectives: To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fractures. Materials and Methods: This study included 56 patients and 31 control subjects. The patients included were those aged >= 65 years who were admitted to our hospital with a diagnosis of bone fracture. The control group comprised age-matched, healthy individuals. Levels of serum vitamin D and GLP-1 were measured and compared between the 2 groups. Results: Significant differences were noted between the groups in terms of serum levels of vitamin D (p < 0.001) and serum levels of GLP-1 (p < 0.001). A positive correlation was observed between serum levels of vitamin D and GLP-1. Conclusion: Serum levels of GLP-1 were found to be significantly lower in elderly patients with bone fracture compared to healthy adults. In addition, a significant correlation was found between decreased vitamin D and GLP-1 levels. These results may therefore demonstrate the protective effects of GLP-1 on bone structure and metabolism, similar to those of vitamin D.