Acute Effects of Levosimendan and Dobutamine on QRS Duration in Patients with Heart Failure


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YONTAR O. C. , YILMAZ M. B. , YALTA K., ERDEM A., TANDOĞAN İ.

ARQUIVOS BRASILEIROS DE CARDIOLOGIA, vol.95, no.6, pp.738-742, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1590/s0066-782x2010005000143
  • Title of Journal : ARQUIVOS BRASILEIROS DE CARDIOLOGIA
  • Page Numbers: pp.738-742

Abstract

Background: Levosimendan is a novel inotropic agent that enhances cardiac contractility without increasing cellular calcium intake, so that it is not supposed to cause intracellular calcium overload and related arrhythmias. In patients with heart failure, prolonged QRS duration is associated with increased risk of mortality and sudden cardiac death. Structural changes in the left ventricle may lead to asynchronous contraction, causing conduction delay and a prolonged QRS on the surface electrocardiogram.