Synthesis of 3,5-Diarylcyclohex-2-enones by NH4Cl/HCl-Catalyzed Cyclization and Deacetylation of 4-Acetylhexane-1,5-diones

Gezegen H., Ceylan M.

HELVETICA CHIMICA ACTA, cilt.98, ss.253-259, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1002/hlca.201400168
  • Dergi Adı: HELVETICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.253-259
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

A new route for the synthesis of 3,5-diarylcyclohex-2-enones is reported. The 4-acetyl-1,3-diarylhexane- 1,5-diones were obtained by the addition of pentane-2,4-dione to chalcones. The reaction of 4-acetyl-1,3-diarylhexane-1,5-diones with NH4Cl/HCl in EtOH under reflux conditions gave the 3,5-diarylcyclohex- 2-enones in good yields. All synthesized compounds were characterized by spectroscopic methods (H-1-, C-13-NMR, and IR), and elemental analyses.