ABO Blood Groups and Clinical Outcomes in Crimean-Congo Hemorrhagic Fever: Insights From a Large Turkish Cohort.

Journal of tropical medicine, cilt.2026, ss.3461989, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 2026
Basım Tarihi: 2026
Doi Numarası: 10.1155/jotm/3461989
Dergi Adı: Journal of tropical medicine
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO)
Sayfa Sayıları: ss.3461989
Sivas Cumhuriyet Üniversitesi Adresli: Evet

Crimean–Congo hemorrhagicfever(CCHF)isatick-borneviraldiseaseinwhichhost-relatedfactorscontributingtodisease

susceptibility andclinicaloutcomesremainincompletelyunderstood.WeaimedtoevaluatetheimpactofABOandRhblood

groups onsusceptibilityandprognosisinpatientswithCCHFandtoinvestigatetheirrelationshipwithepidemiologicalchar-

acteristics inalargereal-worldcohort.Thisretrospectivestudyincluded1143adultpatientswithPCR-conBrmedCCHFwhowere

followed atourcenterbetweenApril2015andSeptember2024.ABOandRhbloodgroupsweredeterminedusingtheHitachi

ElecSys 2010Racksystem,andhematological,biochemical,andcoagulationparameterswereevaluatedsimultaneouslywith

CCHF PCRtestingathospitaladmission.Clinicaloutcomes,viralload,epidemiologicalcharacteristics,diseaseseverityaccording

to theSeverityGradingScore(SGS),andlaboratoryBndingswerecomparedamongbloodgroups.Inaddition,multivariable

logistic regressionanalysiswasperformedtoidentifyindependentpredictorsofin-hospitalmortality.Ofthe1143patients,732

(64.0%) weremaleand411(36.0%)werefemale;548patientshadbloodgroupA,353groupO,154groupB,and88groupAB.

Overall in-hospitalmortalitywas8.5%(97/1143).NosigniBcantdiHerenceswereobservedamongABOorRhbloodgroups

regarding in-hospitalmortality,intensivecareunit(ICU)requirement,viralload,orreportedtickexposure.Althoughnodeathsor

ICU admissionsoccurredintheABRh-negativesubgroup,thissubgroupcomprisedonly13patients.SigniBcantdiHerenceswere

identiBed onlyinamylaseandlipaselevelsamongbloodgroups,whereasSGS,ferritin,interleukin-6,andotherlaboratory

parameters werecomparable.Inthemultivariateanalysis,ABOandRhbloodgroupswerealsonotindependentlyassociatedwith

in-hospital mortality.TheseBndingssuggestthatABOandRhbloodgroupsarenotassociatedwithclinicallymeaningfuldif-

ferences indiseaseseverityorprognosisinpatientswithCCHF.Furthermulticenterprospectivestudiesarewarrantedtovalidate

these Bndings