An Examination of Paraoxonase 1 Gene Polymorphism inCases of Chronic Otitis Media

DURMUŞ K., KÜÇÜK KURTULGAN H., BORA A., YILDIRIM M. E., ALTUNTAŞ E. E.

ENT Updates, cilt.10, sa.1, ss.232-237, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.32448/entupdates.594272
  • Dergi Adı: ENT Updates
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.232-237
  • Anahtar Kelimeler: Otitis media, oxidative stress, paraoxonase-1, genetic polymorphism, SERUM PARAOXONASE, OXIDATIVE STRESS, PON1 GENE, ARYLESTERASE ACTIVITIES, ASSOCIATION, EXPRESSION, RADICALS, EFFUSION, DISEASE, Q192R
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: Chronic otitis media (COM) is a multifactorial disorder, the pathogenesis of which has yet to be fully elucidated. Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokines, endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation which lies at the heart of the disorder. The aim of this study is to investigate a possible relationship between the pathogenesis of COM and polymorphism within the paraoxonase 1 (PON1) gene.