eNOS G894T Polymorphism and Abdominal Aortic Aneurysms

Atli F. H., MANDUZ Ş., Katrancioglu N., ÖZÜM Ü., DİŞLİ O. M., Atahan E., ...Daha Fazla

ANGIOLOGY, cilt.61, sa.2, ss.125-130, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/0003319709339589
  • Dergi Adı: ANGIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.125-130
  • Anahtar Kelimeler: aortic aneurysm, abdominal, eNOS gene polymorphism, human, nitric oxide, NITRIC-OXIDE SYNTHASE, GENE POLYMORPHISM, GLU298ASP POLYMORPHISM, DISEASE, ASSOCIATION, INHIBITION, HUMANS, ALLELE
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background: The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm ( AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase ( eNOS) gene polymorphism with AAA. Methods: eNOS gene polymorphism of 61 patients with AAA and 62 control participants were analyzed by polymerase chain reaction (PCR)-restriction technique. Results: eNOS G894 homozygote T/T genotype polymorphism and 894T allele frequency in patients with AAA were significantly higher than those of the control participants (P=.01, P=.03). Among patients with AAA, the eNOS G894 T/T polymorphism and 894T allele frequency were associated with larger AAAs. Conclusion: The current study, in a small group of participants, showed a relationship between eNOS G894T polymorphism and AAA.