eNOS G894T Polymorphism and Abdominal Aortic Aneurysms
ANGIOLOGY, cilt.61, sa.2, ss.125-130, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 61 Sayı: 2
- Basım Tarihi: 2010
- Doi Numarası: 10.1177/0003319709339589
- Dergi Adı: ANGIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.125-130
- Anahtar Kelimeler: aortic aneurysm, abdominal, eNOS gene polymorphism, human, nitric oxide, NITRIC-OXIDE SYNTHASE, GENE POLYMORPHISM, GLU298ASP POLYMORPHISM, DISEASE, ASSOCIATION, INHIBITION, HUMANS, ALLELE
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
Background: The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm ( AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase ( eNOS) gene polymorphism with AAA. Methods: eNOS gene polymorphism of 61 patients with AAA and 62 control participants were analyzed by polymerase chain reaction (PCR)-restriction technique. Results: eNOS G894 homozygote T/T genotype polymorphism and 894T allele frequency in patients with AAA were significantly higher than those of the control participants (P=.01, P=.03). Among patients with AAA, the eNOS G894 T/T polymorphism and 894T allele frequency were associated with larger AAAs. Conclusion: The current study, in a small group of participants, showed a relationship between eNOS G894T polymorphism and AAA.