The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

Celik N., Alp H., Camtosun E., Alp E., Celik S., Berk E.

HORMONE RESEARCH IN PAEDIATRICS, cilt.87, sa.1, ss.7-14, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1159/000452445
  • Dergi Adı: HORMONE RESEARCH IN PAEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7-14
  • Anahtar Kelimeler: Premature adrenarche, Echocardiography, Carotid intima-media thickness, Epicardial adipose tissue, Periaortic adipose tissue, EPICARDIAL ADIPOSE-TISSUE, PERIAORTIC FAT THICKNESS, INTIMA-MEDIA THICKNESS, CAROTID-ARTERY INTIMA, LEFT-VENTRICULAR MASS, METABOLIC SYNDROME, OBESE CHILDREN, PRECOCIOUS PUBARCHE, OVARIAN HYPERANDROGENISM, INSULIN-RESISTANCE
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Aim: The aim of this study was to investigate the cardiovascular risk of children with premature adrenarche (PA). Methods: A total of 75 children (44 with PA and 31 control subjects) aged 6-10 years were included in the study. Their metabolic, anthropometric, and echocardiographic parameters were recorded and compared. Results: Triglyceride, DHEASO 4, and 17-hydroxyprogesterone levels were significantly higher in the PA group (p = 0.04, p = 0.002, and p = 0.01, respectively). The echocardiographic assessments revealed that the left ventricular end-diastolic diameter (LVEDD) (p < 0.001), left ventricle (LV) and right ventricle (RV) ejection times (p = 0.031 and p = 0.035, respectively), and LV and RV Tei index measurements (p = 0.033 and p = 0.006, respectively) were significantly higher in the PA group than in the control group, whereas the E/e' ratio of the mitral lateral annulus was significantly lower in the PA group (p = 0.006). Additionally, carotid intima-media thickness and epicardial adipose tissue measurements were significantly increased in the PA group compared to the control group (p < 0.001). Conclusion: Early atherosclerotic changes and subclinical impairment of cardiac function were observed in children with PA. It is possible that these children are on a course for early cardiovascular disease. (C) 2016 S. Karger AG, Basel