POMEGRANATE SEED EXTRACT ATTENUATES CHEMOTHERAPY-INDUCED LIVER DAMAGE IN AN EXPERIMENTAL MODEL OF RABBITS


Yildirim N. C. , KANDEMİR F. M. , Ceribasi S., Ozkaraca M. , Benzer F.

CELLULAR AND MOLECULAR BIOLOGY, cilt.59, ss.1842-1847, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 59
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1170/218
  • Dergi Adı: CELLULAR AND MOLECULAR BIOLOGY
  • Sayfa Sayıları: ss.1842-1847

Özet

The aim of this study was to determine whether antioxidant pomegranate seed extract (PSE) has a preventive effect on cisplatin-induced hepatotoxicity. Rabbits were divided into 3 groups (n=6): 1-Control group (0.9 % saline. i.p) 2-Cisplatin group (a single dose of cisplatin (5 mg/kg, i.p) 3-A single dose of cisplatin (5 mg/kg, i.p) + PSE (250 mg/kg/day, i.p) for 6 consecutive days before and 6 consecutive days after a single intraperitoneal dose of 5 mg/kg body weight cisplatin. Liver function enzymes and malondialdehyde (MDA) levels were found significantly higher in cisplatin group compared to control. Liver catalase (CAT) and glutathione peroxidase (GSH-P-X) activities decreased with cisplatin treatment but glutathione (GSH) level was increased. In cisplatin + PSE group, liver function enzyme activities and tissue MDA levels were found lower than cisplatin group. PSE ameliorated cisplatin-induced pathological changes. As a result it was demonstrated that PSE has protective effects against cisplatin hepatotoxicity in rabbit.