Investigation of ternary hydrophobic magnetic deep eutectic solvents for the selective extraction of acrylamide from processed food samples: Ultrasonic-assisted dispersive liquid-liquid microextraction and chemometric optimization

ELİK A., Ul Haq H., FESLİYAN S., ALTUNAY N.

Journal of Molecular Liquids, cilt.411, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 411
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.molliq.2024.125715
  • Dergi Adı: Journal of Molecular Liquids
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Anahtar Kelimeler: Acrylamide, Box-Behnken design, Dispersive liquid–liquid microextraction, Food analysis, Magnetic deep eutectic solvents
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

The aim of this research paper is to develop and investigate the feasibility of an ultrasonic-assisted ternary hydrophobic magnetic deep eutectic solvent-based dispersive liquid–liquid microextraction (UA-HMDES-DLLME) procedure for the selective, rapid and reliable extraction of acrylamide from processed food products. Ultrasonic energy was used for dispersion. HMDES made of octylimidazole, Dysprosium(III) chloride (DyCl3) and palmitic acid with a molar ratio (3:1:3) were used as extraction solvents. Tetrahydrofuran (THF) was used as a dispersive solvent. Microextraction factors of the UA-HMDES-DLLME procedure (ultrasonic time, pH, HMDES volume, and THF volume) were optimized using Box-Behnken Design. Following the optimization stage, the analytical properties of the UA-HMDES-DLLME procedure were determined using the optimum conditions (ultrasonic time: 4.5 min, pH: 4.4, HMDES volume 315 µL, and THF volume, 290 µL). The limits of detection and quantification were 0.6ng mL−1 and 2ng mL−1 respectively. Extraction efficiency and relative standard deviation of the method were 94.4–96.4 % and 1.7–3.6 %, respectively. The method was found to be linear in the concentration range 2-500ng mL−1 with an enhancement factor of 152.4. In conclusion, the UA-HMDES-DLLME procedure has been successfully used for the extraction and determination of acrylamide in processed food samples and certified reference materials.