Alternate Method for the Synthesis of Six-Membered Carbocycles with Five Stereocenters: 1,2,3,4,6-Pentasubstituted-4-hydroxy-cyclohexanes

Gezegen H., Ceylan M.

SYNTHETIC COMMUNICATIONS, cilt.45, ss.2344-2349, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1080/00397911.2015.1080845
  • Dergi Adı: SYNTHETIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2344-2349
  • Anahtar Kelimeler: Domino reactions, one-pot chemoselective synthesis, pentasubstituted cyclohexanol, MULTICOMPONENT DOMINO REACTIONS, ORGANIC-SYNTHESIS, NATURAL-PRODUCTS, KOSTANECKIS TRIKETONE, ATOM ECONOMY, ALDEHYDES, ANALOGS, TANDEM
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

A series of novel 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes (3a-u) were synthesized from the reaction of aromatic ketones with aromatic aldehydes under mild reaction conditions in good yields. The stereochemistry of the synthesized compounds was established using 1D and 2D-NMR spectra.