Serum Levels of Mannan-Binding Lectin in Patients with Crimean-Congo Hemorrhagic Fever


ENGİN A. , UĞURLU S. , Caglar E., ÖZTOP A. Y. , İNAN D. , ELALDI N. , ...More

VECTOR-BORNE AND ZOONOTIC DISEASES, vol.10, no.10, pp.1037-1041, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 10
  • Publication Date: 2010
  • Doi Number: 10.1089/vbz.2009.0060
  • Title of Journal : VECTOR-BORNE AND ZOONOTIC DISEASES
  • Page Numbers: pp.1037-1041

Abstract

Objective: Mannan-binding lectin (MBL) is a central component of the innate immune response. Genetic variations in the MBL gene that reduce circulating levels and alter functional properties of the MBL are associated with susceptibility for many infectious diseases. Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by an arbovirus in the family Bunyaviridae. We have investigated serum MBL levels in CCHF patients and a possible association between circulating MBL concentrations and the severity of CCHF.