Antibiotics in water are receiving increased attention due to their biological effects and potential risks to the environment and human health. Various techniques for the removal of drug active ingredients from wastewater have been extensively studied, including biological processes, coagulation, sedimentation, adsorption, ozonization, photo-catalysis, and photo-electro catalysis. Pharmaceuticals, cosmetics, biomedical, personal care products (PCPs), endocrine disrupting chemicals (EDCs) and flame retardants are very important among anthropogenic contaminants reaching the environment. Most of the macro and micro pollutants in the hospital wastewater that reach the urban wastewater treatment systems without any pre-treatment in many places in our country, reach the recipient environments without being metabolized, creating long-term serious problems in the water resources. Tetracycline (TC), which has an important place among these, is one of the most widely used drug active substances, which has significant effects on human health, and therefore, appropriate approaches are needed to eliminate it. Among various antibiotics, TC is widely used to treat human diseases and raise lifeboats because of its great therapeutic value. As the way of removal; Tetracycline electrochemical oxidation at titanium anode followed a first order kinetics, but TC removal efficiency reached 52.8% in 60 minutes. Effective factors on tetracycline degradation kinetics include current density, pH, and initial TC concentration. By comprehensively analyzing the effective factors of TC electrochemical oxidation in titanium anode and the pathway of complete degradation, our research provides deeper insights by evaluating intermediate and risks and identifying new perspectives for practical electrochemical oxidation to effectively eliminate quantity and toxicity.