Effects of NO/L-Arginine Pathway on Gallbladder Contractility in Bile Duct Ligated Guinea Pigs


Soylu S., AYDIN C. , BAĞÇİVAN İ. , YILDIRIM Ş. , Koyuncu A., Topcu O., ...More

JOURNAL OF SURGICAL RESEARCH, vol.155, no.1, pp.70-76, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 155 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jss.2008.08.002
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.70-76

Abstract

Background. Common bile duct ligation (CBDL) produces gallbladder distension and acute inflammation similar to that seen in human acute acalculous cholecystitis. CBDL in the guinea pig affects smooth muscle contractility. The aim of this study was to determine whether the nitric oxide-L-arginine pathway plays a role in the inflammatory process and abnormal gallbladder contractility that occur after CBDL.