This study evaluated tensile bond strength of a denture soft lining material to a poly (methylmethacrylate) (PMMA) denture base resin subjected to different surface treatment modalities and thermocycling. The materials tested were a silicone-based liner, Molloplast B (R), and a heat-cured denture base resin, Meliodent (TM). The denture soft lining material was packed against cured PMMA base resin, which was smoothed; sandblasted with 250-mu m Al2O3 particles; or lased with a KTP laser; or against uncured PMMA dough (n = 10). In each group, five specimens were thermocycled in a water bath (5-55 degrees C; 3000 cycles) before testing, whereas the other five were directly tested after 24 h. A tensile test was performed using a universal testing machine. Data showed that different treatment modalities of resin surfaces affected adhesion between these two materials and the highest bond values were recorded for cured/smoothed samples under each condition tested. Thermocycling of specimens had no significant reducing effect on measured bond strength values.