Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension

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Ogretmen Z., HIZ M. M., SILAN F., ULUDAĞ A., ÖZDEMİR Ö.

ANNALS OF SAUDI MEDICINE, cilt.34, sa.4, ss.340-345, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5144/0256-4947.2014.340
  • Dergi Adı: ANNALS OF SAUDI MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.340-345
  • Sivas Cumhuriyet Üniversitesi Adresli: Hayır

Özet

BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of endothelial nitric oxide synthase (eNOS Glu298Asp) gene polymorphism in hypertensive and/or non-hypertensive psoriatic patients (2) to investigate the possible relationship between the eNOS Glu298Asp polymorphism and the risk of hypertension among psoriatic patients in the Turkish population.