Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries.
European journal of medicinal chemistry, cilt.37, sa.6, ss.519-23, 2002 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 6
- Basım Tarihi: 2002
- Doi Numarası: 10.1016/s0223-5234(02)01374-0
- Dergi Adı: European journal of medicinal chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.519-23
- Anahtar Kelimeler: potassium channel openers, acridindione, synthesis
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
In this study, 1;2 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and. their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11 > pinacidil > 7 > 2 > 8 > 3 > 1 > 4 > 10 > 6 > 9 > 5 > 12. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.