The therapeutic effect of continuous intracisternal L-arginine infusion on experimental cerebral vasospasm


Goksel H., Ozum U., Oztoprak I.

ACTA NEUROCHIRURGICA, cilt.143, sa.3, ss.277-285, 2001 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 143 Konu: 3
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1007/s007010170108
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Sayfa Sayıları: ss.277-285

Özet

Background. Recent studies on the pathogenesis of cerebral vasospasm following subarachnoid haemorrhage (SAH) suggest a breakdown of the balance between the vasoconstrictor and vasodilator systems. A shortage of a major cerebral vasodilator, nitric oxide (NO), has been accused of causing this breakdown. We investigated the effect of continuous intracisternal infusion of a NO precursor, L-Arginine, in a rabbit SAH model.