The therapeutic effect of continuous intracisternal L-arginine infusion on experimental cerebral vasospasm

Goksel H., Ozum U., Oztoprak I.

ACTA NEUROCHIRURGICA, vol.143, no.3, pp.277-285, 2001 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 143 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1007/s007010170108
  • Title of Journal : ACTA NEUROCHIRURGICA
  • Page Numbers: pp.277-285


Background. Recent studies on the pathogenesis of cerebral vasospasm following subarachnoid haemorrhage (SAH) suggest a breakdown of the balance between the vasoconstrictor and vasodilator systems. A shortage of a major cerebral vasodilator, nitric oxide (NO), has been accused of causing this breakdown. We investigated the effect of continuous intracisternal infusion of a NO precursor, L-Arginine, in a rabbit SAH model.