The therapeutic effect of continuous intracisternal L-arginine infusion on experimental cerebral vasospasm

Goksel H., Ozum Ü., Oztoprak I.

ACTA NEUROCHIRURGICA, cilt.143, sa.3, ss.277-285, 2001 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 143 Sayı: 3
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1007/s007010170108
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.277-285
  • Anahtar Kelimeler: cerebral ischemia-transient, endothelium-derived relaxing factor, L-arginine, nitric oxide, TRANSCRANIAL DOPPLER ULTRASOUND, SUBARACHNOID HEMORRHAGE, NITRIC-OXIDE, PLASMINOGEN-ACTIVATOR, SUPEROXIDE-DISMUTASE, BASILAR ARTERY, ENDOTHELIUM, FLUID, CGRP, DOGS
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background. Recent studies on the pathogenesis of cerebral vasospasm following subarachnoid haemorrhage (SAH) suggest a breakdown of the balance between the vasoconstrictor and vasodilator systems. A shortage of a major cerebral vasodilator, nitric oxide (NO), has been accused of causing this breakdown. We investigated the effect of continuous intracisternal infusion of a NO precursor, L-Arginine, in a rabbit SAH model.