Akademik Veri Yönetim Sistemi
Biocomposites: Advances in Research and Applications, James R. Bush, Editör, Nova Science Publishers, Inc., New York, ss.105-140, 2023
Abstract
Biomaterial scientists are
interested in boron as a dopant element because of its natural functions in
human hard tissues. However, boron does not exist in its elemental form in
nature. Instead, it reacts with oxygen to form boric acid (H3BO3). Boron occurs
naturally as borates, including orthoborate 𝐵𝑂3 3−, metaborate 𝐵𝑂2
−, or tetraborate 𝐵4𝑂7 2−, or as any salt
containing these anions, such as sodium metaborate, 𝑁𝑎+[𝐵𝑂2
] − , and borax (Na+ )2[𝐵4𝑂7 ]
2- . Boron exerts a range of biological effects, including impacts on
reproduction and embryogenesis, promoting wound healing and enhancing responses
to injury or infection, influencing calcium and bone metabolism, and benefiting
central nervous function. It also affects the presence or function of various
hormones, such as thyroid hormone, insulin, estrogen, and progesterone, as well
as calcium, magnesium, and vitamin D, which are involved in hard tissue
metabolism. Research conducted at the molecular level has demonstrated that
boron can increase RNA transcription within placental nuclei and activate mRNA
translation, particularly for growth factors involved in wound repair and the
formation of new blood vessels (angiogenesis). This chapter will provide a
summary of the recent advances in the development of boron biomaterials that
respond to specific biomedical applications.
Keywords: biomedical
applications, boron, chronic wounds, ion-substitution, responsive biomaterials