Long-term assessment of bone formation in response to Gen Os and Gel 40 xenografts in an experimental rat model

Develioglu H., ÜNVER SARAYDIN S., Akkus Z., Sahin Z. D., BAKAR O.

BIOMEDICAL RESEARCH-INDIA, cilt.26, sa.4, ss.666-671, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2015
  • Dergi Adı: BIOMEDICAL RESEARCH-INDIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.666-671
  • Anahtar Kelimeler: critical-sized defect, xenograft, bone regeneration, parietal bone, MULTINUCLEATED GIANT-CELLS, CALVARIAL DEFECT MODEL, PERIODONTAL DEFECTS, EXTRACTION SOCKETS, BIO-OSS, REPAIR, AUGMENTATION, SURGERY, HUMANS
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

The study's aim was to assess long-term bone healing associated with two different xenografts in an experimental model of parietal bone defects in rats. We surgically created two symmetrical, full-thickness, parietal bone defects 5 mm in diameter in each of 12 rats, which were then divided randomly into three groups (eight defects per group): group 1, defects filled were with Gen Os; group 2, defects were filled with Gel 40; and group 3 (control) defects were left empty. There was substantial bone formation in group 1, but no to minimal bone formation was seen in the other groups. Significant differences were observed between groups 1 and 2 and groups 1 and 3 (p < 0.05 for both). Gen Os and Gel 40 were both osteoconductive and biocompatible. Based on the long-term outcomes in our study, Gen-Os xenograft is more conducive to bone regeneration, but further studies are required.