Debonding at the composite-adhesive interface is a major problem for indirect composite restorations. The aim of this study was to evaluate the bond strength (BS) of an indirect composite resin after various surface treatments (air-abrasion with Al2O3, phosphoric acid-etchig and different applications of NdYAG laser irradiations). Fifty composite disks were subjected to secondary curing to complete polymerization and randomly divided into five experimental groups (n=10) including Group 1, untreated (control); Group 2, phosphoric acid-etched; Group 3, air-abrasion with Al2O3; Group 4, Nd:YAG laser irradiated with non-contact and Group 5, Nd:YAG laser irradiated with contact. They were then bonded to resin cement and shear BS was determined in a universal testing device at a crosshead speed of 1mm/min. One way analysis of variance (ANOVA) and Tukey post-hoc tests were used to analyze the BS values. The highest BS value was observed in Group 4 and followed by Group 3. Tukey test showed that there was no statistical difference between Group1, 2 and 5. Furthermore, differences in BSs between Group 4 and the other groups except Group 3 were significant (p<0.05) and also there were significant differences in BSs between Group 3 to 1 and Group 3 to 2 (p<0.05). This study reveals that air-abrasion with Al2O3 and Nd:YAG laser irradiation with non-contact provided a significant increase in BS between indirect composite and resin cement. SCANNING 37:89-94, 2015. (c) 2014 Wiley Periodicals, Inc.