Research Information System
8 th HAGIA SOPHIA INTERNATIONAL CONFERENCE ON MULTIDISCIPLINARY SCIENTIFIC STUDIES, İstanbul, Turkey, 11 - 12 September 2024, pp.295-300
Non-Hodgkin Lymphoma (NHL) is the most commonly observed hematologic malignancy worldwide, characterised by the abnormal clonal proliferation of lymphoid cells originating from lymph nodes or extranodal lymphatic tissues. Its incidence is rising globally. The relationship between smoking and cancer has been established in previous studies, and the association between smoking and various types of lymphoma has also been explored in the literature. In patients with non-Hodgkin lymphoma, alterations in various hematologic parameters at diagnosis can influence disease prognosis. However, as is well known, smoking affects hematologic parameters such as WBC and hemoglobin. This study aims to identify hematologic and prognostic changes in NHL patients who smoke. The study included 189 patients diagnosed with NHL. The patients' records were retrospectively reviewed to collect data on age, gender, hemogram values at diagnosis (WBC, hemoglobin, lymphocytes, platelets), and smoking status. In NHL patients, those who smoked had statistically significantly higher WBC and hemoglobin values compared to non-smokers (p<0,05). However, neither elevated WBC, hemoglobin levels, nor smoking demonstrated a statistically significant impact on treatment response (p>0,05). In conclusion, smoking is known to influence both the etiology and prognosis of many cancer types. However, our study did not demonstrate the impact of smoking on prognosis (p>0,05). Given that NHL is a highly heterogeneous disease with over 60 distinct subtypes, we concluded that further studies with larger sample sizes across different subtypes are needed.