Investigation of the applicability of fatty acid-based deep eutectic solvent based air assisted liquid liquid microextraction for the rapid determination and extraction of butylparaben in cosmetic products


Altunay A. Ö., ELİK A.

Sustainable Chemistry and Pharmacy, vol.30, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30
  • Publication Date: 2022
  • Doi Number: 10.1016/j.scp.2022.100884
  • Journal Name: Sustainable Chemistry and Pharmacy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Fatty acid -deep eutectic solvents, Experimental design, UV, Vis spectrophotometry, Butylparaben, Cosmetic products
  • Sivas Cumhuriyet University Affiliated: Yes

Abstract

In this research paper, fatty acid-based deep eutectic solvents (FA-DESs) were prepared and investigated for the extraction of butylparaben (BP) from cosmetic products by air assisted liquid liquid microextraction (AA-DLLME). The amounts of BP were determined by UV/Vis spectrophotometry. By combining single factor optimization and Box-Behnken design based multivariate approach, key extraction parameters affecting the FA-DES AA-LLME procedure were systematically optimized. Under the optimized conditions, wide working range (5–800 μg L−1) was obtained with a good r2:0.9972 and high enrichment factor (205). For three replications run of 10 μg L−1 (low), 300 μg L−1 (medium) and 600 μg L−1 (high) of BP, the percent extraction recovery and relative standard deviation were in the range of 92 ± 4%-98 ± 2% and 1.8–2.6%, respectively. The limit of detection and the limit of quantification were 1.5 μg L−1 and 5 μg L−1, respectively. The study of the matrix effect showed that the proposed method has high selectivity for measuring BP in the selected samples. Therefore, it has great potential in sample pre-treatment and quantification of trace BP in cosmetic products.