Investigation of the applicability of fatty acid-based deep eutectic solvent based air assisted liquid liquid microextraction for the rapid determination and extraction of butylparaben in cosmetic products
Sustainable Chemistry and Pharmacy, cilt.30, 2022 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/j.scp.2022.100884
- Dergi Adı: Sustainable Chemistry and Pharmacy
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Fatty acid -deep eutectic solvents, Experimental design, UV, Vis spectrophotometry, Butylparaben, Cosmetic products
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
In this research paper, fatty acid-based deep eutectic solvents (FA-DESs) were prepared and investigated for the extraction of butylparaben (BP) from cosmetic products by air assisted liquid liquid microextraction (AA-DLLME). The amounts of BP were determined by UV/Vis spectrophotometry. By combining single factor optimization and Box-Behnken design based multivariate approach, key extraction parameters affecting the FA-DES AA-LLME procedure were systematically optimized. Under the optimized conditions, wide working range (5–800 μg L−1) was obtained with a good r2:0.9972 and high enrichment factor (205). For three replications run of 10 μg L−1 (low), 300 μg L−1 (medium) and 600 μg L−1 (high) of BP, the percent extraction recovery and relative standard deviation were in the range of 92 ± 4%-98 ± 2% and 1.8–2.6%, respectively. The limit of detection and the limit of quantification were 1.5 μg L−1 and 5 μg L−1, respectively. The study of the matrix effect showed that the proposed method has high selectivity for measuring BP in the selected samples. Therefore, it has great potential in sample pre-treatment and quantification of trace BP in cosmetic products.