The effects of sildenafil in liver and kidney injury in a rat model of severe scald burn: a biochemical and histopathological study

GÖKAKIN, ALİ; ATABEY, MUSTAFA; DEVECİ, KÖKSAL; SANCAKDAR, ENVER; TUZCU, MEHMET; DÜGER, CEVDET; TOPÇU, ÖMER

doi:10.5505/tjtes.2014.39586

The effects of sildenafil in liver and kidney injury in a rat model of severe scald burn: a biochemical and histopathological study

GÖKAKIN A. K., ATABEY M., DEVECİ K., SANCAKDAR E., TUZCU M., DÜGER C., ...Daha Fazla

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.20, sa.5, ss.319-327, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 5
Basım Tarihi: 2014
Doi Numarası: 10.5505/tjtes.2014.39586
Dergi Adı: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.319-327
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

BACKGROUND: Severe burn induces systemic inflammation and reactive oxygen species leading to lipid peroxidation which may play role in remote organs injury. Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific phosphodiesterase-5. Sildenafil reduces oxidative stress and inflammation in distant organs. The aim of the present study was to evaluate the effects of different dosages of sildenafil in remote organs injury.