The effects of sildenafil in liver and kidney injury in a rat model of severe scald burn: a biochemical and histopathological study


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GÖKAKIN A. K. , ATABEY M. , DEVECİ K. , SANCAKDAR E. , TUZCU M. , DÜGER C. , ...Daha Fazla

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.20, ss.319-327, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5505/tjtes.2014.39586
  • Dergi Adı: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
  • Sayfa Sayıları: ss.319-327

Özet

BACKGROUND: Severe burn induces systemic inflammation and reactive oxygen species leading to lipid peroxidation which may play role in remote organs injury. Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific phosphodiesterase-5. Sildenafil reduces oxidative stress and inflammation in distant organs. The aim of the present study was to evaluate the effects of different dosages of sildenafil in remote organs injury.