Effect of imatinib on growth of experimental endometriosis in rats

YILDIZ, ÇAĞLAR; KAÇAN, TURGUT; BOZOKLU AKKAR, ÖZLEM; KARAKUŞ, SAVAŞ; Seker, Metin; Kacan, Selen; ÖZER, HATİCE; ÇETİN, ALİ

doi:10.1016/j.ejogrb.2015.12.013

Effect of imatinib on growth of experimental endometriosis in rats

YILDIZ Ç., KAÇAN T., BOZOKLU AKKAR Ö., KARAKUŞ S., Seker M., Kacan S. B., ...Daha Fazla

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.197, ss.159-163, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 197
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.ejogrb.2015.12.013
Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.159-163
Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which are widely used drugs for endometriosis, is usually not possible due to their suboptimal safety and tolerance profile. The lack of an effective, tolerable and safe treatment option for endometriosis makes animal models of experimental endometriosis necessary to study candidate drugs. The aim of this study was to investigate the efficacy of imatinib on the experimental endometriosis in a rat model.