Effect of imatinib on growth of experimental endometriosis in rats


YILDIZ Ç. , KAÇAN T. , BOZOKLU AKKAR Ö. , KARAKUŞ S. , Seker M., Kacan S. B. , ...Daha Fazla

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.197, ss.159-163, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 197
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.ejogrb.2015.12.013
  • Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
  • Sayfa Sayıları: ss.159-163

Özet

Objective: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which are widely used drugs for endometriosis, is usually not possible due to their suboptimal safety and tolerance profile. The lack of an effective, tolerable and safe treatment option for endometriosis makes animal models of experimental endometriosis necessary to study candidate drugs. The aim of this study was to investigate the efficacy of imatinib on the experimental endometriosis in a rat model.