Prognostic value of the systemic immune-inflammation index, systemic inflammation response index, and prognostic nutritional index in head and neck cancer

Atasever Akkas E., ERDİŞ E., YÜCEL B.

European Archives of Oto-Rhino-Laryngology, cilt.280, sa.8, ss.3821-3830, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 280 Sayı: 8
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00405-023-07954-6
  • Dergi Adı: European Archives of Oto-Rhino-Laryngology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.3821-3830
  • Anahtar Kelimeler: Head and neck cancer, Systemic immune-inflammation index, Systemic inflammation response index, Prognostic nutritional index
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Purpose: This study sought to investigate the prognostic value of the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and prognostic nutritional index (PNI) in patients with head and neck cancer. Methods: The data of 310 patients with head and neck cancer who were referred to the Radiation Oncology Clinic of Sivas Cumhuriyet University Faculty of Medicine (n = 271, 87%) and to S.B.U. Dr. Abdurrahman Yurtaslan Ankara Oncology Health Practice and Research Centre (n = 39, 13%) between January 2009 and March 2020 were retrospectively analysed. At the time of diagnosis, patients’ neutrophil, lymphocyte, monocyte, platelet and albumin levels were used to calculate their SII, SIRI and PNI indices. Results: Multivariate analysis found the after variables to be independent prognostic factors for overall survival (OS): SII [hazard ratio (HR) 1.71, 95% confidence interval (CI) 1.18–2.47; p = 0.002] and PNI (HR 0.66, 95% CI 0.43–0.97; p = 0.038), stage (HR 2.11, 95% CI 1.07–4.16; p = 0.030), fraction technique (HR 0.49, 95% CI 0.28–0.85; p = 0.011) and age (HR 2.51, 95% CI 1.77–3.57; p = 0.001).The following variables were found to be independent prognostic factors for disease-free survival (DFS) in multivariate analysis: SII (HR 2.16, 95% CI 1.22–3.83; p = 0.008), fractionation technique (HR 0.17, 95% CI 0.004–0.64; p = 0.017) and age (HR 2.11, 95% CI 1.13–3.93; p = 0.019). Conclusion: This study found a high SII to be an independent poor prognostic factor for both OS and DFS, while a low PNI was found to be an independent poor prognostic factor only for OS.