The aim of this study was to detemiine haptoglohin (Hp), serum amyloid-A (SAA) and ceruloplasmin (Cp) levels in naturally occurring cases of coryza gangrenosa bovum (CGB). The study was conducted on 14 animals, where 7 were sick cattle clinically diagnosed with CGB (patient group), and 7 healthy cattle from the same region (control group). It was determined that the general clinical examination results (rectal temperature, heart and respiratory frequency and rumen movement) detected in the patient group of animals showed significant differences (P(0.001) with respect to the animals in the control group. Serum Hp, SAA and Cp concentrations in the animals in the control group were detemiined as 0.22 +/- 0.02 mg/mL 13.96 +/- 0.79 mu g/mL, and 8.10 +/- 2.85 mg/dL respectively, but 0.75 +/- 0.20 mg'nI 182.25 +/- 22.63 mgMI, and 9.40 +/- 2.54 mg/dL respectively for the patient group. It was detennined that SAA(P<0.001) and Hp (P<0.05) concentrations of the cattle in the patient group were significantly enhanced, while the increase in Cp levels were observed to he insignificant (P>0.05). Consequently, serum SAA and Hp concentrations in the cattle with CGB infection increased significantly in the acute phase of the disease, and it was concluded that further in-depth studies should he conducted on more animals in order to reveal the clinical significance of these changes in CGB infections, and also for precise diagnosis of CGB.