It aimed that traditional text compression methods are using on compression of DNA sequence in this study. It has seen that the random short repeats are vital and it has examined their posivite impact for compression. A pipelined system with multiple algorithms running sequentially for compression. How the contribution of the algorithm to the system was investigated and especially the effect of the BWT on compression was shown. Results show that the pipeline system was found unable to catch the compression success of the Huffman coding alone.